Wound Healing

Wound healing is the process by which skin or other body tissue repairs itself after trauma. In undamaged skin, the epidermis (surface layer) and dermis (the deeper layer) form a protective barrier against the external environment. When the barrier is broken, an orchestrated cascade of biochemical events is set into motion to repair the damage. This process is divided into predictable phases: hemostasis (blood clotting), inflammation, tissue growth and proliferation, and tissue remodeling or maturation.

The wound healing process is both complex and fragile, and it is susceptible to interruption or failure, leading to the formation of non-healing chronic wounds. Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age.

Advancements in the clinical understanding of wounds and their pathophysiology have commanded significant biomedical innovations in the treatment of acute, chronic, and other types of wounds. Many biologics, skin substitutes, bio-membranes, and scaffolds have been developed to facilitate wound healing through various mechanisms (2). Wound healing is a complex and dynamic process of restoring cellular structure and tissue layers. Future advances in wound healing will focus on the agents that influence the repair of damaged tissue. This may include laser techniques, stem cells, fetal tissue, and other modalities that enhance the proliferation and migration of cells, and acceleration of the healing process (3).

Oxygen Therapy products OTI-1011 can improve the supply of oxygen to wounded tissue and potentially accelerate healing. It can be applied together with any of the above treatment modalities.

(2) Vyas KS, Vasconez HC. Wound Healing: Biologics, Skin Substitutes, Biomembranes and Scaffolds. Healthcare. 2014; 2(3): 356-400

(3) The 2015 Physician’s Guide to the Wound Institute®